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The patent on Revatio (indicated for pulmonary arterial hypertension rather than erectile dysfunction) expired in late 2012.Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.Teva Canada launched Novo-Sildenafil, a generic version of Viagra,.Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose).See also: Drugs for erectile dysfunction and premature ejaculation.Drugs for erectile dysfunction ( G04BE ) and premature ejaculation.Generic Active Best Online Prices Viagra 20mg Levitra Super. Generic Viagra Forum Uk.Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation ( vasodilation ) of the intimal cushions of the helicine arteries.

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Main page Contents Featured content Current events Random article Donate to Wikipedia Wikipedia store.Plus Through Paypal Viagra Purchase Super Active Viagra Online.Help About Wikipedia Community portal Recent changes Contact page.Do not take VIAGRA (sildenafil citrate) if you: take any medicines called nitrates, often prescribed for chest pain, or guanylate.

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Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum.The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse).This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.

Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes.Viagra at The Periodic Table of Videos (University of Nottingham).

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Methylation of 3-propylpyrazole-5-carboxylic acid ethyl ester with hot dimethyl sulfate.The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further.Caution is advised in those who have cardiovascular disease.

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Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles.Sildenafil Citrate affects the response to sexual stimulation.

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