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This is a type of high blood pressure that occurs between the heart and the lungs.

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Safety of sildenafil citrate: review of 67 double-blind placebo-controlled trials and the postmarketing safety database.FDA Safety Changes: Off-Label Use of Sildenafil Not Recommended in Children With PAH.

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The approximately 4,000-fold selectivity for PDE5 versus PDE3 is important because PDE3 is involved in control of cardiac contractility.Pfizer initially targeted the drug to treat male erectile dysfunction, but some PAH specialists prescribed the drug for off-label use to their patients.This medicine may cause the following problems: Low blood pressure (especially if taken with other medicines that lower blood pressure) Heart problems Painful or prolonged erection Vision or hearing problems Keep all medicine out of the reach of children.More detailed version of this drug page Truven Health Analytics, an IBM company, Disclaimer The information contained in the Truven Health Analytics products is intended as an educational aid only.

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Do not take other medicines that contain sildenafil or similar medicines, such as tadalafil or vardenafil.Sildenafil citrate 100 mg starting dose in men with erectile dysfunction in an international, double-blind, placebo-controlled study:.

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You will probably begin at a low dose and be asked to build up to a target maintenance level.This will increase the supply of blood to the lungs and reduce the workload of the heart.

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