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Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.And when we come alive, the What Is Viagra Ingredient comes along.Our clinicians regularly offer patients the opportunity to take part in trials of new drugs and treatments.Psychostimulants (e.g., amphetamines, cocaine, methylphenidate ).

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There are also mouth spray preparations of sildenafil for faster onset of action.

Caution is advised in those who have cardiovascular disease.

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In February 2007, it was announced that Boots, the UK pharmacy chain, would try over-the-counter sales of Viagra in stores in Manchester, England.

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Sildenafil should not be used if sexual activity is inadvisable due to underlying cardiovascular risk factors (such as recent heart surgery, stroke or heart attack, etc.).

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It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease ).The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further.

According to the FDA, you may want to be careful about what is in your coffee.See also: Drugs for erectile dysfunction and premature ejaculation.

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Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose).

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Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects.

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